mautic.ERROR: [MAIL ERROR] Expected response code 250 but got an empty response

We are experiencing the same issue with Mautic 4.0.1 with Amazon SES. The weird thing is that some emails are going through.

We are running a campaign with around 300,000 contacts, and I am seeing the log start to fill up and also noticing lots of failed events.

In the system log I am getting messages like this:

[2021-11-18 18:24:51] mautic.ERROR: [MAIL ERROR] Expected response code 250 but got an empty response (send); kfdsfd@wfdsf.com {"exception":"[object] (Swift_TransportException(code: 0): Expected response code 250 but got an empty response at /var/www/mautic/vendor/swiftmailer/swiftmailer/lib/classes/Swift/Transport/AbstractSmtpTransport.php:447)"} []

in the contact card I see this message and that it has been rescheduled to send later this evening:

Not sure how to go about debugging this. So any ideas would be greatly welcome