Make Mautic useful for people with multiple newsletters / blogs / brands

I want to send emails to my entire list that are associated with particular Segments, and have the unsubscribes correspond with that Segment only.

For example, Brand A is Segment A and Brand B is Segment B – I want to be able to put all my contacts in both segments, then when I send a newsletter, specify which segment the newsletter is attached to. Then if a contact unsubscribes from a Segment A newsletter, it only unsubscribes them from Segment A, and not Segment B.