How to handle "out of office" bounced mails

I have a campaign which will send 33000 mails. All works fine, but I got 900 »Out of office« replies which will handled as »Do not contact«. Is the reason the bounce management? How to deal with such mails? How can I avoid that such mails are marked as bounced?

I have a campaign which will send 33000 mails. All works fine, but I got 900 »Out of office« replies which will handled as »Do not contact«. Is the reason the bounce management? How to deal with such mails? How can I avoid that such mails are marked as bounced?